What We Do 2017-04-25T18:22:49+00:00

Our Mission

Microbial Pharmaceuticals’ goal is to develop the largest, functional library of natural products (through the most robust discovery platform) in order to facilitate a new pipeline of chemical matter into early stage pharmaceutical testing. We have comprised a team of scientists that are well established in the various fields of natural products. Our team offers the necessary expertise and knowledge to bring the metabologenomics platform into thousands of strains of bacteria.

How We Plan To Accomplish This

We plan on creating a pipeline (on an unprecedented scale) to feed compounds from the natural world into pharmaceutical research. Our innovative software, NPkinect, will allow users to sort through natural products of their interest and find related compounds in the same molecular family.

  • Firstly, Microbial Pharmaceuticals plans to run our platform on a pilot phase of 50-200 strains as a proof of concept that our platform is functional.
  • Next, we will incorporate this data into our NPkinect software in order to “fine tune” the platform.
  • We will then move to apply metabologenomics across more strains and continually incorporate this data into our ever-growing NPkinect software.
  • Lastly, we will develop partnerships with major pharmaceuticals and provide them access to our highly curated natural product library in order to accelerate the “drugs from bugs” pipeline.

How We Cultivate Our Natural Products

We grow single strains of bacteria and characterize its natural products using state-of-the-art analytical instrumentation. This data is then combined with the metabolomic information from hundreds of strains and implemented into our metabologenomics dataset and eventually NPkinect.

Who Does This Benefit?

Natural products have been honed for thousands of years to interact with real biological systems which makes them very valuable lead compounds for drug development, but their discovery has been a bottleneck in the past. Microbial Pharmaceuticals will alleviate this bottleneck resulting in partnerships with major pharmaceutical companies to deliver much-needed drugs to the world.

Why Investers Should Back Microbial Pharmaceuticals

Microbial Pharmaceuticals offers investors an opportunity to establish a partnership in developing an unprecedented platform for harnessing the future pharmaceutical drugs from the natural world.

These natural products could be used as lead compounds for the development of pharmaceuticals, or used for gaining a better understanding of how diseases (such as cancer) can be targeted for treatment. These compounds and understandings will provide a major improvement to human health outcomes.

Glossary Of Terms

A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.
A natural products discovery platform that fuses metabolomics and genomics to increase the throughput of discovery.
A strain is a genetic variant or subtype of a micro-organism (e.g., virus or bacterium or fungus).
Bacteria are single celled microbes. The cell structure is simpler than that of other organisms as there is no nucleus or membrane bound organelles. Instead their control centre containing the genetic information is contained in a single loop of DNA.
A compound is a substance formed when two or more chemical elements are chemically bonded together.
Microbial Pharmaceutical’s innovative software for navigating the complexity of natural product chemical space.
A group of natural products that exhibit structural similarity and are likely related through biosynthesis.

Actinobacteria is a phylum of Gram-positive bacteria with high guanine and cytosine content in their DNA. Although understood primarily as soil bacteria, they might be more abundant in freshwaters. Considered to be one of the most prolific producers of natural products.

Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones).
High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material.
Mass Spectrometry (MS) is an analytical chemistry technique that helps identify the amount and type of chemicals present in a sample by measuring the mass-to-charge ratio and abundance of gas-phase ions.

A biological system is a complex network of biologically relevant entities. As biological organization spans several scales, examples of biological systems are populations of organisms, or on the organ- and tissue scale in mammals and other animals, the circulatory system, the respiratory system, the nervous system, etc.
On the micro- to the nanoscopic scale, examples of biological systems are cells, organelles, macromolecular complexes and regulatory pathways.